Faculty Members
Dr Abdur Rub
Assistant Professor
Office Address:
Deptt.of Biotechnology,
Jamia Millia Islami,
New Delhi - 110025
abdurrub81@gmail.com (Primary)
Research Focus:
Pathogens and their hosts have had a two-way chat for millions years. This interaction has led to several measure/counter-measure reactions by the host and pathogen. The host immune system has developed numerous ways to neutralize and get rid of them. In turn, pathogens have also developed mechanisms to alter and evade the host immune response. Leishmania, a protozoan parasite, clearly manipulates the host to alter the immune responses. Leishmania causes leishmaniasis which is endemic in 88 countries including India, with a total of 12 million people infected worldwide and 350 million people at risk of infection. The molecular mechanisms and consequences of host immune evasion by Leishmaniaare poorly defined. My laboratory is interested in defining these molecular mechanisms and interactions of immune evasion. I currently investigated Leishmania disrupts macrophage-membrane lipid raft and impairs p38-mitogen-activated protein kinase (p38MAPK)-mediated CD40 signaling but enhances extracellular signal-related kinase (Erk-1/2)-mediated signalling. Activation of p38MAP kinase induces pro-inflammatory cytokines like IL-12 which inhibits the growth and survival of parasite while activation of Erk-1/2 induces IL-10 production which aggravates the infection.
Awards, Honours and Research Fellowships:
- INSA Medal for Young Scientists –2012 by Indian National Science Academy, India
- CSIR-SRF byCouncil of Scientific & Industrial Research (CSIR), India, 2007-2010
- CSIR-JRF by Council of Scientific & Industrial Research (CSIR), India, 2005-2007
- National Eligibility Test (NET)by University Grant Commission (UGC) India,2004
- Graduate Aptitude Test in Engineering (GATE), by IIT Delhi, India, 2004
- National Merit Scholarship from UP Board Allahabad, India,1996-2001
Research /Teaching Experience:
- Assistant Professor in theDeptt. of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi (Oct. 2011 to till date)
- Assistant Professor in the Deptt. of Toxicology at Hamdard University, New Delhi Aug. 2010 to Oct. 2011
- Postdoc Fellow at Immune Disease Institute, Harvard University, Boston, USA (April 2010 to Aug. 2010)
- Ph.D from National Centre for Cell Science, Pune (2005 to 2010)
- Junior Research Fellow at National Centre for Biological Sciences (NCBS-TIFR), Bangalore (2004-2005)
Selected Publications:
- Abdur Rub,Dey, R., Jadhav, M., Kamat R., Majumdar, S,. Mukhopadhyay, R & Saha, B. Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nat. Immunol. 2009,10(3):273-280. (Impact factor ~27)
- Majumder S, Dey R, Bhattacharjee S, Abdur Rub, Gupta G, Bhattacharyya Majumdar S, Saha B, Majumdar S. Leishmania-induced biphasic ceramide generation in macrophages is crucial for uptake and survival of the parasite. J Infect Dis. 2012,15;205(10):1607-1616. (Impact factor ~6)
