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    • Dr. Sadaf Fatima

    Assistant Professor

    Office Address:
    Department of Biotechnology,
    Jamia Millia Islamia (Central University),
    New Delhi 110025

    Education, Training & Experience

    2009

    PhD, Department of Biotechnology, Aligarh Muslim University (CSIR-JRF/SRF)-

    2004

    M.Sc., Department of Biotechnology, Aligarh Muslim University (Gold Medallist)

    2002

    B.Sc., Department of Biochemistry, Aligarh Muslim University- 2002

    2011-Present

    Assistant Professor, Department of Biotechnology, Jamia Millia Islamia, New Delhi

    January 2010- June, 2010

    Worked as Research Scientist in International Traceability Systems Limited, New Delhi

    Dec. 2008- Dec. 20092

    Worked as Project Associate at National Institute of Immunology (NII) New Delhi.

    Lab Members : Ph.D. Guidance

    1. Chandani Praveen
    2. Romana Parveen
    3. Tooba N. Shamsi
    4. Mohsin Munshi
    5. Shweta Agrawal

    Photo Gallery: Medical Biotechnology Laboratory

    Not Available

    Research Overview

    Protein aggregation is the conversion of monomers into aggregates which prevent the normal functioning of the protein. Certain conditions like ageing, gene alteration and environmental stress lead to changes in protein conformation and subsequent deposition of misfolded protein. Research is focused on addressing problem of protein aggregation that is responsible for a number of diseases like Alzheimer’s disease.  Aggregation of proteins therapeutics during their industrial production, storage or transportation may lead to huge economic losses. Nanotechnology based approach is used to deal with aggregation problem. Research for new bioactive compounds, from Ayurvedic herbs is also in progress, which can target aggregation related diseases.

    Research Projects

    1. DST-SERB: [No. SR/FT/LS-194/2009], Duration: 2012-2015, Amount: 22 lakhs
    2. UGC-BSR: [F.20-1(24)/2012(BSR)], Duration: 2012-2014, Amount: 6 lakhs
    3. DBT: [BT/PR18844/NNT/28/1047/2016], Duration: 2017-2020, Amount: 60 lakhs
    4.  AYUSH: [Z.28015/06/2017-HPC (EMR)-AYUSH-C] Duration: 2018-2021: 50 lakhs

    Research Publications, Reviews & Book Chapters

    1. Nanoclay based study on protein stability and aggregation and its implication in human health. Parveen R, Tarannum Z, Ali S, Fatima S. Int J Biol Macromol. 2020, doi:10.1016/j.ijbiomac.2020.10.197.
    2. Phytochemical analysis and In-vitro Biochemical Characterization of aqueous and methanolic extract of Triphala, a conventional herbal remedy. Parveen R, Shamsi TN, Singh G, Athar T, Fatima S. Biotechnol Rep (Amst). 2018 Feb 8;17:126-136. doi: 10.1016/j.btre.2018.02.003.
    3. Trypsin Inhibitors from Cajanus cajan and Phaseolus limensis Possess Antioxidant, Anti-Inflammatory, and Antibacterial Activity. Shamsi TN, Parveen R, Afreen S, Azam M, Sen P, Sharma Y, Haque QMR, Fatma T, Manzoor N, Fatima S. J Diet Suppl. 2018 Nov 2;15(6):939-950. doi: 10.1080/19390211.2017.1407383.
    4. Panchakola Reduces Oxidative Stress in MCF-7 Breast Cancer and HEK293 Cells. Shamsi TN, Parveen R, Fatima S. J Diet Suppl. 2018 Sep 3;15(5):704-714. doi: 10.1080/19390211.2017.1386255.
    5. Structural and Biophysical Characterization of Cajanus cajan Protease Inhibitor. Shamsi TN, Parveen R, Ahamad S, Fatima S. J Nat Sci Biol Med. 2017 Jul-Dec;8(2):186-192. doi: 10.4103/0976-9668.210018.
    6. A review on protein misfolding, aggregation and strategies to prevent related ailments. Shamsi TN, Athar T, Parveen R, Fatima S. Int J Biol Macromol. 2017 Dec;105(Pt 1):993-1000. doi: 10.1016/j.ijbiomac.2017.07.116.
    7. Trypsin inhibitors demonstrate antioxidant activities, inhibit A549 cell proliferation, and increase activities of reactive oxygen species scavenging enzymes. Shamsi TN, Parveen R, Fatima S. Indian J Pharmacol. 2017 Mar-Apr;49(2):155-160. doi: 10.4103/ijp.IJP_553_16.
    8. Biophysical insight into structure-function relation of Allium sativum Protease Inhibitor by thermal, chemical and pH-induced modulation using comprehensive spectroscopic analysis. Shamsi TN, Parveen R, Naz H, Haque MA, Fatima S. Int J Biol Macromol. 2017 Oct;103:415-423. doi: 10.1016/j.ijbiomac.2017.05.075. Epub 2017 May 17.
    9. A novel multicopper oxidase (laccase) from cyanobacteria: Purification, characterization with potential in the decolorization of anthraquinonic dye. Afreen S, Shamsi TN, Baig MA Ahmad N, Fatima S, Qureshi MI, Hassan MI, Fatma T. PLoS One. 2017 Apr 6;12(4):e0175144. doi: 10.1371/journal.pone.0175144. eCollection 2017.
    10. Purification and characterization of a novel trypsin-like protease from green-seeded chickpea (Cicer arientum). Shamsi TN, Parveen R, Sen P, Fatima S. Prep Biochem Biotechnol. 2017 May 28;47(5):513-519. doi: 10.1080/10826068.2017.1292291.
    11. Allium sativum Protease Inhibitor: A Novel Kunitz Trypsin Inhibitor from Garlic Is a New Comrade of the Serpin Family. Shamsi TN, Parveen R, Amir M, Baig MA, Qureshi MI, Ali S, Fatima S. PLoS One. 2016 Nov 15;11(11):e0165572. doi: 10.1371/journal.pone.0165572. eCollection 2016.
    12. Nanoparticles-protein interaction: Role in protein aggregation and clinical implications. Parveen R, Shamsi TN, Fatima S. Int J Biol Macromol. 2017 Jan;94(Pt A):386-395. doi: 10.1016/j.ijbiomac.2016.10.024.
    13.  pH induced single step shift of hydrophobic patches followed by formation of an MG state and an amyloidogenic intermediate in Lima Bean Trypsin Inhibitor (LBTI). Khan JM, Alsenaidy MA, Khan MS, Sen P, Khan RH, Fatima S. Int J Biol Macromol. 2017 Oct;103:111-119. doi: 10.1016/j.ijbiomac.2017.05.040.
    14. Crossroad Intermediates as ‘Folding Pathway’ Control Mechanism of Gene Expression. Fatima S. Austin Journal of Biotechnology & Bioengineering. 2017; 4(2): 1075.
    15. Characterization, biomedical and agricultural applications of protease inhibitors: A review. Shamsi TN, Parveen R, Fatima S. Int J Biol Macromol. 2016 Oct;91:1120-33. doi: 10.1016/j.ijbiomac.2016.02.069.
    16. Harmful effect of detergents on lipase. Fatima S, Ajmal R, Badr G, Khan RH. Cell Biochem Biophys. 2014 Nov;70(2):759-63. doi: 10.1007/s12013-014-9978-4.
    17. pH-Induced molten globule state of Rhizopus niveus lipase is more resistant against thermal and chemical denaturation than its native state. Rabbani G, Ahmad E, Zaidi N, Fatima S, Khan RH. Cell Biochem Biophys. 2012 Apr;62(3):487-99. doi: 10.1007/s12013-011-9335-9.
    18. Methyl cyanide induces alpha to beta transition and aggregation at high concentrations in E-state of human serum albumin. Sen P, Iqbal MA, Fatima S, Khan RH. Biochemistry (Mosc). 2010 Mar;75(3):367-74.
    19. More stable structure of wheat germ lipase at low pH than its native state. Ahmad E, Fatima S, Khan MM, Khan RH. Biochimie. 2010 Jul;92(7):885-93. doi: 10.1016/j.biochi.2010.03.023.
    20. Interactions of thioflavin T with serum albumins: spectroscopic analyses. Sen P, Fatima S, Ahmad B, Khan RH. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Sep 15;74(1):94-9. doi: 10.1016/j.saa.2009.05.010.
    21. Stability check of succinylated concanavalin A: presence of functionally active conformational state. Fatima S, Khan RH. Protein Pept Lett. 2009;16(4):423-9.
    22. How methyl cyanide induces aggregation in all-alpha proteins: a case study in four albumins. Sen P, Fatima S, Khan JM, Khan RH. Int J Biol Macromol. 2009 Mar 1;44(2):163-9. doi: 10.1016/j.ijbiomac.2008.11.008.
    23. Characterization of fluoroalcohols-induced intermediates of Mucor miehei lipase at low pH. Fatima S, Mishra A, Sen P, Khan RH. Protein Pept Lett. 2008;15(4):346-52.
    24. fect of polyethylene glycols on the function and structure of thiol proteases. Fatima S, Khan RH. J Biochem. 2007 Jul;142(1):65-72.