Education, Training & Experience

Lab Members

Dr. Archana Sharma (Postdoc), ICMR-RA

Registration: 2019- Present

Ph.D. (Neurobiology)- University of Rajasthan

Email-  archanagmsharma@gmail.com

Mohd Junaid Khan, UGC-MANF JRF

Ph.D. Scholar: 2015- Present

Email - mohd.khanj@gmail.com

 

Shaniya Ahmad, ICMR-SRF

Ph.D. Scholar: 2016- Present

Email: shaniya169053@st.jmi.ac.in

Co-Supervisor: Dr. Kailash Manda

Shweta Arora, ICMR- SRF

Ph.D. Scholar: 2016- Present

Email: shweta.khannabt@gmail.com

Co-supervisor – Dr. Askandar Iqbal

Kavita Sharma, ICMR-SRF

Ph.D. Scholar: 2016- Nov 2021

Email: kavita2688@gmail.com

Co-supervisor – Dr. M. A. Qadar Pasha

Mohd Mohsin, CSIR-JRF

Ph.D. Scholar: 2020- Present

Email: rs.mmohsin@jmi.ac.in    

 

Salman Khan, CSIR- JRF

Ph.D. Scholar: 2020 – Present

Email: khansalman1@outlook.in

Ph.D. students under Co-supervision:

Gulnaz Tabassum, CSIR NET

Ph.D. Scholar: 2021 to present

Email: tabassumgulnaz@yahoo.com

Almaz zaki, ICMR JRF

Ph.D. Scholar: 2019 to present

Email: almazzaki1122@gmail.com

Photo Gallery: Translational Research Laboratory

×

1 / 5

2 / 5

3 / 5

4 / 5

5 / 5

❮ ❯

Research Overview

The overall focus of my research is to improve understanding of the etiopathogenesis of Acute Lung Injury and sepsis and find innovative methods to prevent and manage these diseases. To achieve this, I have been doing bench and translational research covering the myriad aspects of these complex disorders. The focus of my research has been in understanding hyperoxia, LPS and sepsis-induced lung injury in the mature and developing lung, a major factor in causing ARDS and other lung diseases.

Research Projects

1. Role of miRNAs in lung development and injury- Ramanujan Fellowship Research Grant - SERB  : PI (Completed)
2. Role of mitophagy in macrophage polarization and sepsis-induced acute lung injury- Core Research Grant SERB-DST : PI
3. Integrating effects of Vitamin D and miRNAs in Lung Development and Injury- DBT: PI
4. The role of miRNAs in metabolism and macrophage polarization in Non- small cell lung cancer (NSCLC)- ICMR : PI

Research Publications, Reviews & Book Chapters

1. Shweta Arora, Prithvi Singh, Shaniya Ahmad, Tanveer Ahmad, Ravins Dohare, Saleh A Almatroodi, Faris Alrumaihi, Arshad Husain Rahmani, Mansoor Ali Syed (2021) Comprehensive Integrative Analysis Reveals the Association of KLF4 with Macrophage Infiltration and Polarization in Lung Cancer Microenvironment. Cells 10;8, 291[IF: 6.4]
2. Archana Sharma, Shaniya Ahmad, Tanveer Ahmad, Shakir Ali, Mansoor Ali Syed (2021) Mitochondrial dynamics and mitophagy in lung disorders. Life Sciences, 119876 [IF: 5.1]
3. Ashif Iqubal, Mohd Wasim, Mohd Ashraf, Abul Kalam Najmi, Mansoor Ali Syed, Javed Ali, Syed Ehtaishamul Haque (2021) Natural Bioactive as a Potential Therapeutic Approach for the Management of Cyclophosphamide-induced Cardiotoxicity. Current Topics in Medicinal Chemistry [IF: 3.29]
4. Kavita Sharma, Neha Chanana, Ghulam Mohammad, Tashi Thinlas, Mohit Gupta, Mansoor Ali Syed, Rajat Subhra Das, Qadar Pasha, Aastha Mishra (2021) Hypertensive Patients Exhibit Enhanced Thrombospondin-1 Levels at High-Altitude. Life, 11;9 [IF: 3.81]
5. Kavita Sharma, Prithvi Singh, Md Amjad Beg, Ravins Dohare, Fareeda Athar, SYED MA (2021) Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach. Gene, 80;1 [IF: 3.68]
6. Kavita Sharma, Aastha Mishra, Himanshu N Singh et al., Syed MA, MA Pasha (2021) High-altitude pulmonary edema is aggravated by risk-loci and associated transcription factors in HIF-prolyl hydroxylases. Human molecular genetics, ddab139 [IF: 6.1]
7. M Mohsin, G Tabassum, S Ahmad, S Ali, Syed MA (2021) The Role of Mitophagy in Pulmonary Sepsis. Mitochondrion 59, 63-75 [IF: 4.2]
8. S Khan, M Masood, H Gaur, S Ahmad, Syed MA (2021) Long non-coding RNA: An immune cells perspective. Life Sciences, 119152 [IF: 5.09]
9. Singh P, Sharma A, R Jha, S Arora, R Ahmad, AH Rahmani, Syed MA (2020) Transcriptomic analysis delineates potential signature genes and miRNAs associated with the pathogenesis of asthma. Scientific reports 10 (1), 1-13 [IF: 4.4]
10.  Khan MJ, Singh P, Dohare R, R Jha, AH Rahmani, SA Almatroodi, S Ali, Syed MA (2020) Inhibition of miRNA-34a Promotes M2 Macrophage Polarization and Improves LPS-Induced Lung Injury by Targeting Klf4. Genes 11 (9), 966 [IF: 4.1]
11. Arora S, P Singh, R Dohare, R Jha, Syed MA (2020) Unravelling host-pathogen interactions: ceRNA network in SARS-CoV-2 infection (COVID-19). Gene 145057 [IF: 3.68]
12. S Ahmad, S Arora, S Khan, M Mohsin, A Mohan, K Manda. Syed MA (2020). Vitamin D and its therapeutic relevance in pulmonary diseases. The Journal of Nutritional Biochemistry, 108571 [IF: 6.1]
13. Bhatt S, Singh P, Sharma A, A Rai, R Dohare, S Sankhwar, A Sharma, Syed MA (2020) Deciphering key genes and miRNAs associated with Hepatocellular carcinoma via network-based approach. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2020/8/14 [IF: 3.7]
14. Arora S, Singh P, AH Rahmani, SA Almatroodi, R Dohare, Syed MA (2020) Unravelling the Role of miR-20b-5p, CCNB1, HMGA2 and E2F7 in Development and Progression of Non-Small Cell Lung Cancer (NSCLC) Biology 9 (8), 201. [IF: 5.1]
15. Das P, Curstedt T, Agarwal B, Syed MA, Salomone F, Casiraghi C, Pelizzi N, Bhandari V. (2020) Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- And Hyperoxia-Induced Lung Injury in Preterm Rabbits. Frontiers in Physiology. 2020 Apr 9; 11:266. [IF: 4.5]
16. Almatroodi SA, Almatroudi A, Alsahli MA, Aljasir MA, Syed MA, Rahmani AH (2020) Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression. Molecules. 2020 Jun 20;25(12):2853. doi: 10.3390/molecules25122853. [IF: 4.4]
17.  R Ahmad, M Khan, P Mishra, N Jahan, MA Ahsan, I Ahmad, MR Khan, Syed MA (2020) Engineered hierarchical CuO nanoleaves based electrochemical nonenzymatic biosensor for glucose detection. Journal of the Electrochemical Society 168 (1), 017501 [IF: 4.3]
18. Iqubal A, Syed MA, Ali J, Najmi AK, Haque MM, Haque SE (2020) Nerolidol protects the liver against cyclophosphamide-induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF-κB p65, and caspase-3 signaling molecules in Swiss albino mice. Biofactors, 2020 Sep 17. doi: 10.1002/biof.1679 [IF: 6.1]
19. Iqubal A, Syed MA, Najmi AK, F Azam, GE Barreto, MK Iqubal, J Ali, Haque SE (2020) Nano-engineered nerolidol loaded lipid carrier delivery system attenuates cyclophosphamide neurotoxicity–Probable role of NLRP3 inflammasome and caspase-1. Experimental Neurology, 113464 [IF: 5.33]
20. Syed MA, Das P, Pawar A, Aghai ZH, Kaskinen A, Zhuang ZW, Ambalavanan N, Pryhuber G, Andersson S, Bhandari V (2017) Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lung. Nature Communications, 8(1): 1173 [IF: 14.91]
21. Iqbal MA, Arora S, Prakasam G, Calin GA, Syed MA (2018) MicroRNA in lung cancer: Role, mechanisms, pathways and therapeutic relevance. Molecular Aspects of Medicine, 2018 Aug 10. doi: 10.1016/j.mam.2018.07.003. [IF: 14.3]
22. Iqubal A, Syed MA Najmi AK, Ali J, Alam MM, Haque SE (2019) Ameliorative effect of nerolidol on cyclophosphamide‐induced gonadal toxicity in Swiss Albino mice: Biochemical‐, histological‐ and immunohistochemical‐based evidences Andrologia. May;52(4):e13535. [IF: 2.77]
23. Piersigilli F, Syed MA, et al., Pietro Bagolan, and Vineet Bhandari (2020) An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, Microrna and metabolomic profiling. Journal of Perinatology. 2020 Feb 20 [IF: 2.5]
24. Singh P, Rai A, Dohare R, Arora S, Ali S, Parveen S, Syed MA. (2020) Network-based Identification of Signature Genes KLF6 and SPOCK1 Associated with Oral Submucous Fibrosis. Molecular and Clinical Oncology. 2020 Feb 20
25. Ahmed R, Khan M, Tripathy, N et. al, Syed MA, Khosla A (2020) Nano-donuts shaped nickel oxide nanostructures for sensitive non- enzymatic electrochemical detection of glucose. https://doi.org/10.1007/s00542-020-04754-4. Microsystem Technologies.  [IF: 2.27]
26. Ahmad S, Singh P, Sharma A, Arora A,  Shriwash N,   Rahmani  AH,    Almatroodi SA, and Syed MA. (2019) Transcriptome Meta-Analysis Deciphers a Dysregulation in Immune Response- Associated Gene Signatures during Sepsis. Genes, 10, 1005; doi:10.3390/genes10121005. [IF: 4.1]
27. Pragnya D, et al Syed MA Acharya S. (2019) Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. Scientific Reports, Feb 27;9(1):2904 [IF: 4.37]
28. Ahmad R, Tripathy N, Khosla A, Khan M, et al. Syed MA, and Hahn YB. (2020) Review-Recent Advances in Nanostructured Graphitic Carbon Nitride as a Sensing Material for Heavy Metal Ions. Journal of The Electrochemical Society, 2020167037519. [IF: 4.3]
29. Khan M, Ahmed R, Tripathy, N et al Syed MA. (2019) Fabrication of an ultra-sensitive hydrazine sensor based on nano-chips shaped nickel hydroxide modified electrodes. Microsystem Technologies, https://doi.org/10.1007/s00542-019-04721-8. [IF: 2.27]
30. Pantouris G, Ho J, Shah D, Syed MA, Leng L, Bhandari V, Bucala R, Batista VS, Loria JP, Lolis E. (2018) Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew Chem Int Ed Engl. 2018 Apr 18. doi: 10.1002/anie.201803191. [IF: 15.3]
31. Siddiqui FA, Prakasam G et al., Syed MA and Iqbal MA. (2018) Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition. Scientific Reports, Apr 2018 [IF: 4.3].
32. Arora S, Ahmad S, , Dev K,… Husain M, Ali S, Mohan A, Syed MA (2019) TLRs in pulmonary diseases. Life Sciences. 2019 Sep 15; 233:116671. doi: 10.1016/j.lfs.2019.116671. [IF: 5.03]
33. Iqubal A, Sharma S, Ansari MA, Najmi AK, Syed MA, Ali J, Alam MM, Ahmad S, Haque SE (2019). Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice.  European Journal of Pharmacology. 2019 Sep 18:172666. doi: 10.1016/j.ejphar.2019.172666. [IF: 4.43]
34. Iqubal A, Sharma S, Najmi AK, Syed MA, Ali J, Alam MM, Haque SE (2019). Nerolidol ameliorates cyclophosphamide-induced oxidative stress, neuroinflammation and cognitive dysfunction: Plausible role of Nrf2 and NF- κB. Life Sciences. 2019 Sep 11:116867. doi: 10.1016/j.lfs.2019.116867. [IF: 5.03]
35. Nitesh Shriwash, Prithvi Singh, Shweta Arora, Syed MA, Sher Ali, Ravins Dohare (2019) Identification of differentially expressed genes in small and non-small cell lung cancer based on meta-analysis of mRNA. Heliyon 5 (2019) e01707.
36. Khan V, Sharma S, Bhandari U, Syed MA, Haque SE. (2017) Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats. Life Sciences 1;194: 12: 205-09 [IF: 5.03]
37. Iqubal A, et al., Syed MA, Ali J, Haque SE (2019) Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision. Life Sciences. Feb 1;218: 112-131 {Review} [IF: 5.03]
38. Shweta Arora, Kapil Dev, Beamon Agarwal, Pragnya Das, Syed MA (2017). Macrophages: Their role, activation and polarization in pulmonary diseases. Immunobiology, 223(4-5): 383-88 [IF: 3.14].
39. Pragnya D, Syed MA, Dilip S, Bhandari V (2018) miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia. Cell Stress, Vol. 2, No. 2, pp. 34 - 36; doi: 10.15698/cst2018.02.124
40. Sureshbabu A, Syed MA, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V (2016) Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. American Journal of Respiratory Cell and Molecular Biology, 55(5):722-735. [IF: 6.9]
41. Syed MA, Choo-Wing R, Homer RJ, Bhandari V (2016) Role of Nitric oxide isoforms in vascular and alveolar development and lung injury in vascular endothelial growth factor overexpressing neonatal mice lungs. Plos One 11(1); e0147588. PMID: 26799210 [IF: 3.2]
42. Yuan Z, Syed MA, Panchal D, et al. (2015) TREM-1 accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine. Americal Journal of physiology: Lung, cellular and Molecular physiology 1:310(5): L426-38. PMID: 26684249 [IF: 5.46]
43. Pantouris G*, Syed MA*, Fan C, Rajasekaran D, Cho Y, Rosenberg E, Bucala R, Bhandari V, Lolis EJ (2015). An analysis of MIF structural features that control functional activation of CD74. Chemistry and Biology (Cell Chemical Biology) 17;22(9):1197-205 PMID: 26364929 (*equal contribution) [IF: 8.11]
44. Gamm U, Huang B, Syed MA, Zhang X, Bhandari V, and Choma M (2015). Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry-optical coherence tomography. July 27, 2015, Journal of Biomedical Optics, 20(8):80505 PMID: 26308164 [IF: 3.17].
45. Sureshbabu A, Syed MA, Boddupalli CS, Homer RJ and Bhandari V (2014). Conditional Overexpression of TGFβ1 Promotes Pulmonary Inflammation, Apoptosis and Mortality via TGFβR2 in the Developing Mouse Lungs. Respiratory Research January 16; 16 (1):4. PMID: 25591994 [IF: 5.6]
46. Ranjan R, Lee YG, Karpurapu M, Syed MA, Chung S, Deng J, Jeong JJ, Zhao G, Xiao L, Sadikot RT, Weiss MJ, Christman JW, Park GY (2014). P47-phox and reactive oxygen species production modulate expression of microRNA-451 in macrophages. Free Radical Research. 2015 Jan; 49(1):25-34. PMID: 25287330 [IF: 4.14]
47. Rajasekaran D, Zierow S, Syed MA, Bucala B, Bhandari V, and Lolis EJ (2014) Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. FASEB Journal. 2014 Jul 11, 28(11):4961-71. PMID: 25016026 [IF: 5.19]
48. Lang SM, Syed MA, Dziura J, Rocco E, Kirshbom P, Bhandari V and Giuliano JS (2014) The effect of modified ultrafiltration on angiopoietins in pediatric cardiothoracic surgery. Annals of Thoracic Surgery 98 (5): 1699-1704. PMID: 25258157 [IF: 4.33]
49. Yuan Z, Syed MA, Panchal D, Joo M, Colonna M, Brantly ML, Sadikot RT (2014). TREM-1 mediated Bcl-2 induction prolongs macrophage survival. Journal of Biological Chemistry (JBC). 2014 Apr 7. 289(21): 15118-29. PMID: 24711453 [IF: 4.225]
50. *Syed MA and Bhandari V (2013). Hyperoxia exacerbates postnatal inflammation -induced lung injury in neonatal brp-39 null mutant mice promoting the m1 macrophage phenotype. Mediators of Inflammation. 2013:457189. (*Corresponding Author) PMID: 24318272 [IF: 4.7]
51. Syed MA*, Choo-Wing R*, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ and Bhandari V. (2013) Hyperoxia and interferon-γ induced injury in developing lungs occur via cox2 and the ER stress dependent pathway. American Journal of Respiratory Cell and Molecular Biology Jun; 48(6):749-57. (*equal first authors) [IF: 6.9]
52. Yuan Z, Panchal D, Syed MA, Mehta H, Joo M, Hadid W and Sadikot RT (2013). Induction of cyclooxygenase-2 signaling by stomatococcus mucilaginosus highlights the pathogenic potential of an oral commensal. Journal of Immunology, Oct 1; 191(7):3810-7. PMID: 24018272 [IF: 5.42]
53. Sun H, Choo-Wing R, Fan J, Leng L, Syed MA, Hare AA, Jorgensen WL, Bucala R, Bhandari V (2013). Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia. Respiratory Research. 2013 Feb 28; 14(1):27. PMID: 23448134 [IF: 5.6]
54. Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ (2013). MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proceedings of National Academy Science U S A (PNAS) Jul 2; 110(27): 10994-9. PMID: 23776208 [IF: 11.2]
55. Fu P, Mohan V, Syed MA, Tiruppathi C, Sadikot RT, Natarajan V (2013) Role of NOX proteins in Pseudomonas Aeruginosa induced lung inflammation and permeability. American Journal of Respiratory Cell and Molecular Biology Apr; 48(4):477-88. [IF: 6.9]
56. Yuan Z, Syed MA, Panchal D, Rogers D, Joo M, Sadikot RT (2012). Curcumin mediated epigenetic modulation inhibits TREM-1 expression in response to lipopolysaccharide. International Journal Biochemistry and Cell Biology. Nov; 44(11):2032-43. [IF: 5.08]
57. Rajasekaran D, Keeler C, Syed MA, Jones MC, Harrison JK, Wu D, Bhandari V, Hodsdon ME, Lolis EJ (2012) A model of GAG/MIP-2/CXCR2 interfaces and its functional effects. Biochemistry. 2012 Jul 17; 51 (28):5642-54. [IF: 3.16]
58. Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA (2012) Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. American Journal of Respiratory Cell and Molecular Biology 2012 May; 46(5):668-76. [IF: 6.9]
59. Syed MA, Joo M, Zulfiqar Abbas, Rodger D, Christman JW, Mehta DM, and Sadikot RT (2010). Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. Experimental Cell Research 15; 316(19):3140-9 [IF: 3.9]
60. Syed MA and Jain GC (2013) Hypolipidemic Potential of Bacopa monniera in Cholesterol Fed Rats. Trends in Biosciences 2013, 6(2), 206-209.
61. Jain, GC and Syed MA (2007) Effect of ethanolic extract of Cassia alata (L.) flowers on reproductive functions of male albino rats (2007). Journal of Experimental Zoology India v. 10(1): p. 129-132.

Book/s and Chapters:

1. Syed MA and Husain SY. (2009) Practical Manual of Biotechnology. Aavishkar Publications, 2009, viii, 192 p, ISBN: 81-7910-279-4. (Book)
2. Aggrwal A, Mahajan N, Syed MA,  Paudyal B, Swapan K. Nath, and Shah D. (2016) Reactive Oxygen Species: Physiology and Pathogenesis in Systemic Lupus Erythematosus. Reactive Oxygen Species in Biology and Human Health. CRC Press ISBN: 9781498735452. (Book Chapter)
3. Kavita Sharma, Syed Yawer Husain, Pragnya Das, Mohammad Husain, Syed MA (2017) Regenerative Potential of Mesenchymal Stem Cells: Therapeutic Applications in Lung Disorder.s Vol. 2, Chapter 7, Liver, Lung and Heart Regeneration, Part of the series Stem Cells in Clinical Applications pp 77-117, Springer International  Publishing  AG.  Part   of Springer Nature. ISBN: 978-3-319-46692-7 (Book Chapter)