INFORMATION FOR WEBPAGE

ABOUT

Name	AALIYA TAIYAB
Course	PHD
Date of Admission	01.10.2019
Roll No	201909869
Corresponding Address	PROTEIN RESEARCH LAB G07, CENTRE FOR INTERDISCIPLINARY RESEARCH IN BASIC SCIENCES, Jamia Millia Islamia (JMI), New Delhi, 110025
Corresponding Email	aaliya1909869@st.jmi.ac.in, aaliyataiyab04@gmail.com
Supervisor Name	MD. IMTAIYAZ HASSAN https://hassanlab.org/

NEWS

Date	Events
FEB 2021	PRIME MINISTER RESEARCH FELLOWSHIP

EXPERIENCE (INDUSTRIAL/ACADEMIC)

Training/research fellow

July 2018- October 2019: JUNIOR RESEARCH FELLOW in the DBT- CoEIB project ‘Integration of Plants and parasite omics to decipher the interactions and identify molecular targets for the management of root knot disease of rice’ at Indian Agricultural Research Institute (IARI - ICAR).
2014-2015 – Project on “Biomarkers of Heat Stress and Acclimatization” at DRDO- DIPAS, New Delhi under the University of Delhi Fest Antardhwani.
2013-14 - Internship: innovative Project- DR206 ‘Developing E-governance framework in Daulat Ram College at a position of Intern Management for college website.

EDUCATION

Doctor of Philosophy (Ph.D.)

Centre for Interdisciplinary Research in Basic Sciences, CIRBSc

Jamia Millia Islamia

Completed course work with 85%

Master IN ZOOLOGY

Specialization: Nematology

Aligarh Muslim University, AMU

8.3 CGPA

Bachelor IN ZOOLOGY(HONS)

Daulat Ram College

Delhi University

70%

RESEARCH

Ph.D. Project (Pursuing)

Title: Pharmacological inhibition of MTH1 enzyme for therapeutic management of

cancer and associated disease.

Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The Human MutT Homolog 1 (MTH1 a.k.a Nudix hydrolase 1, NUDT1) protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. Keeping this in view, we will validate MTH1 as an anticancer target and describe certain phytonutrients as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells.

This Research will include:

· Cloning, expression, and purification of MTH1 protein.
· Screening and experimental validation of potential MTH1 inhibitors.
· Cell based evaluation of selected MTH1 inhibitors for their possible therapeutic application.

This project is designed in such a way that it will help therapeutics in fighting the cancer. Future prospects include elaborative work both at molecular as well as at therapeutic level (In-vitro &; in-vivo). Co-crystallization of MTH1-selected inhibitors helps to uncover the structure function relationship. It will also help in studying the complexity of cancer and its pathways. Further, as these enzymes plays an important role in telomere integrity, their elaborative work will be extended towards ageing and other telomere related disorders.This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.

MSc Project (2017)

Title: Description and Embryonic Development of Mesorhabditis saprophila sp. n.

Under the supervision of Prof. Qudsia Tahseen https://amu.ac.in/faculty/zoology/qudsia-tahseen

Aligarh Muslim University (Nematology Division)

The work was concerned with identifying a novel species of a nematode based on its morphology and embryonic development. The species was identified as Mesorhabditis sp. n. belonging to the order Rhabditida. The habitat was typical of most rhabditids which thrive on the substrate rich in organic matter. The morphology was characterized by small-sized body, lip region offset, metastegostom with two denticles, pharyngeal collar short, pharyngeal corpus with faint zipper-like lumen and male with slightly offset lip region, long and slender spicule with head heart shaped and seven pairs of genital pappilae and an abruptly narrowing tail. The life cycle of Mesorhabditis sp. n. was short and its reproductive potential was high as in case of other rhabditis. The embryonic development was traced from fertilized egg to newly hatched larva. The male and female pronuclei was fused in longitudinal plane. The pattern of cleavage was unique from other Rhabditidae upto three-celled stage ( T shaped arrangement).

PUBLICATION

JOURNAL PAPERS

Gupta P, Taiyab A., Hussain A, AlAjmi MF, Islam A, Hassan MI. (2021) Targeting Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery. Cancers https://doi.org/10.3390/cancers13081898

BOOK CHAPTERS

Gupta, P., Taiyab A., Hassan M.I. (2020) Emerging role of protein kinases in diabetes mellitus: From mechanism to therapy. Advances in Protein Chemistry and Structural Biology. https://doi.org/10.1016/bs.apcsb.2020.11.001

CONFERENCES AND WORKSHOP

National Symposium on Therapeutic Advances in Cancer, Dec 2019, Oral presentation, at Jamia Millia Islamia, New Delhi, India.
7th International Cereal Nematodes Symposium, Nov 2019 at IARI-ICAR: Poster Presentation.
Biannual Meeting of Protein Society India, AUH Chapter at Amity University Haryana on Jan 2020
Poster Presentation on the topic “Regulation of TOR pathway in context of pathogenic and symbiotic bacterial interactions with nematodes”. In IS-MPMI XVIII Congress, 2018.

COURSES

Course No	Course name
MPCW01	RESEARCH METHODOLOGY
MPCW02	SEMINAR COMPONENT
MPCW06	ADVANCEMENT IN PROTEIN FOLDING AND DYNAMICS
MPCW07	STRUCTURAL BIOLOGY

AWARDS

Received “Jamia Award of Excellence” for Prime Minister Research Fellowship (PMRF) – 15 August 2021

Awarded Best Poster presentation at 7th International Cereal Nematodes Symposium, IARI-ICAR, on the topic “Management of root-knot nematode Meloidogyne graminicola infecting rice using nematophagous fungus, Talaromyces pinophilus”.